How to Use RU58841: The Two Minute Daily Routine, Step by Step

This is the full protocol. How to apply RU58841 properly, when to use it, what to pair it with, and what to expect in the first few months. No fluff. Just the routine.

The daily routine

1. Start with a dry scalp. Clean is best. If you've just showered, towel dry first.
2. Draw up 1ml. That's one full dropper.
3. Part your hair and dot it onto the thinning areas. Hairline, temples, crown. On the scalp, not the hair.
4. Massage it in lightly with your fingertips for 10 to 15 seconds.
5. Let it dry. The ethanol base dries fast, so no greasy residue. Then style as normal.
6. Once a day, morning or night. Any time works, as long as it's every day.

That's it. The whole thing takes about 60 seconds. Nobody will know you're using it.

If you're using RUstim+

RUstim+ already has RU58841, minoxidil, caffeine and peppermint oil combined. One application a day covers everything. You don't need to layer separate products.

If you're using RU58841 5% on its own

RU58841 5% is just the DHT blocker. If you also use minoxidil separately, put them on at different times of day, one in the morning and one at night. That gives each one time on the scalp without watering the other down.

Microneedling with the dermastamp

Use the dermastamp once a week. 1.5mm depth. Press straight in and lift straight out, in lines across the thinning areas. Takes about 2 minutes.

The stamp makes tiny channels in the scalp. That helps your topicals get in, and sets off your body's repair response. In a study of 100 men, weekly microneedling with 1.5mm needles plus minoxidil grew far more hair in 12 weeks than minoxidil alone (Dhurat 2013).

Important: wait 24 to 36 hours after stamping before applying RU58841 or any topical. If you stamp at 8pm Sunday, don't apply anything before 8pm Monday. Putting it on freshly stamped skin is asking for irritation.

Don't use a derma roller. Rollers go in at an angle and come out at an angle. V shaped tears, which can scar. A stamp goes straight in and straight out. Clean punctures. Better healing.

The scalp massager

Use it daily. While watching TV, at your desk, before you apply, whenever you remember. In a small study, nine men who massaged their scalp for four minutes a day for 24 weeks ended up with thicker hairs (Koyama 2016). No set time. Just use it consistently.

The weekly schedule

A week on the RU58841 protocol

Day	What to do
Monday to Saturday	1ml of RU58841 (or RUstim+), once a day, same time that suits you. Scalp massager whenever.
Sunday	Dermastamp. 1.5mm, 2 minutes across the thinning areas, on a clean, dry scalp.
The day after	Skip your application until 24 to 36 hours have passed since stamping. Then carry on as normal.

Change the stamping day to whatever suits you. The key is consistency. Miss a day here and there, fine. Miss a week, you're slowing your progress.

How well does each one work?

Why this routine? Because each part has numbers behind it. Here are the real numbers from the studies, each one linked so you can check it. Every study measured things a bit differently, so read each line on its own.

• RU58841 on the scalp: strong. In bald monkeys, RU58841 5% raised growing follicles by 103% and turned 26% of thin hairs into thick ones. The finasteride pill got 88% and 12% in the same study, and RU did it with no hormone change. On real balding human scalp grown on mice, 28% of follicles started a new growth cycle with RU, against 7% without it. (Uno monkey study, not on PubMed; same team: Pan 1998, De Brouwer 1997)
• Minoxidil 5%: good. 393 men, 48 weeks. 5% beat the dummy and grew 45% more hair than 2%. It doesn't touch DHT, so it works best next to a DHT blocker. (Olsen 2002)
• Dermastamp (microneedling): a big boost. 100 men, 12 weeks. Weekly microneedling plus minoxidil: hair count up 91.4. Minoxidil alone: up 22.2. 82% said their hair was more than 50% better, against 4.5% on minoxidil alone. (Dhurat 2013)
• Scalp massage: small. 9 men, 4 minutes a day for 24 weeks. Each hair got a bit thicker: 0.085mm to 0.092mm. (Koyama 2016)

Short version: stop the DHT first, then grow the hair. That's a DHT blocker plus minoxidil, with a dermastamp once a week. RUstim+ does the first two in one bottle.

What to expect: the timeline

First 6 to 8 weeks: the shedding phase

You might lose more hair than normal. This is the most common reason people quit early, and it's the worst time to quit. Weak, shrunk hairs are falling out as stronger ones start to push through. It looks worse before it looks better. Stick with it.

Months 2 to 3: early regrowth

Shedding slows down. You start noticing new growth. Thin areas begin to fill in.

Months 4 to 6: visible improvement

Proper density coming back. Less scalp showing. The kind of improvement where you stop checking mirrors and get on with your day.

Months 6 to 12 and beyond

It keeps getting better for a lot of people. Most level off somewhere in the second year. After that it's maintenance. Keep applying daily and you keep what you've grown.

Customer photos at each stage: How Long Does RU58841 Take to Work? and our results page.

Common mistakes

Quitting during the shed. The shedding phase is the product working, not failing. Stopping at week 4 because you're shedding is like leaving the gym after one session because you're sore.

Applying too much. More isn't better. 1ml is enough. Drowning your scalp just wastes product.

Stamping and applying the same day. Wait 24 to 36 hours. Every time.

Inconsistency. This isn't a once a week thing. Daily application is what makes it work. Think of it like brushing your teeth. You do it every day because that's how it works.

Changing products every month. Pick a routine and give it three months.

Not giving it enough time. If you haven't done 3 months consistently, you haven't given it a fair shot. Hair growth cycles are slow.

Need more detail?

How much to use, strength, storage and the science behind the dose: RU58841 Dosage Guide. Worried about side effects? RU58841 Side Effects.

I'm not a doctor and this isn't medical advice. Source: Dhurat and colleagues (2013), Int J Trichology, PubMed 23960389. Koyama and colleagues (2016), Eplasty, PubMed 26904154.

Sources

1. Uno and colleagues. Conference abstract, Wisconsin Regional Primate Research Center. Follicular regrowth with 5α reductase inhibitor (finasteride) or androgen receptor blocker (RU58841) in the bald scalp of the stumptailed macaque. Not on PubMed. Same team's published RU58841 paper: Pan 1998, Endocrine
2. De Brouwer and colleagues (1997). Br J Dermatol. Balding human scalp on mice: 28% of follicles started a new growth cycle on RU58841, 7% without. PubMed 9415227
3. Olsen and colleagues (2002). J Am Acad Dermatol. 5% minoxidil grew 45% more hair than 2%. PubMed 12196747
4. Dhurat and colleagues (2013). Int J Trichology. Weekly microneedling plus minoxidil against minoxidil alone, 100 men. PubMed 23960389
5. Koyama and colleagues (2016). Eplasty. Four minutes of daily scalp massage and hair thickness in nine men. PubMed 26904154